Legalon 70 Mg Side Effects

Derosa G, Romano D, D`Angelo A, Maffioli P. Berberis aristata / Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to high-dose statins: a randomized, placebo-controlled clinical trial. Phytomedicine. 2015;22(2):231-7. See the summary. Kittur, S., Wilasrusmee, S., Pedersen, W. A., Mattson, M. P., Straube-West, K., Wilasrusmee, C., Lubelt, B. and Kittur, D. S. Neurotrophs and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture.

J Mol.Neurosci. 2002;18(3):265-269. See the summary. Some medications are modified and broken down by the liver. Milk thistle can affect how quickly the liver breaks down certain medications. Taking milk thistle with certain medications that are broken down by the liver may increase or decrease the effect of these medications. Before taking milk thistle, talk to your doctor if you are taking medications that are impaired by the liver. Some liver-modified medications include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, verapamil (Calan, Isoptin) and many others. Milk thistle can increase the amount of tamoxifen absorbed by the body.

This may increase the effects and side effects of tamoxifen. Before taking milk thistle, talk to your doctor if you are taking tamoxifen. Zi, X., Mukhtar, H. and Agarwal, R. Novel chemopreventive effects of silymarin flavonoid antioxidant cancer: inhibition of mRNA expression of an endogenous TNF alpha tumor promoter. Biochem.Biophys.Res common. 10-9-1997;239(1):334-339. Guarino G, Strollo F, Carbone L, et al. Bioimpedance analysis, metabolic effects and safety of the Berberis aristata/Bilybum marianum association: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. J Biol Regul Homeost remedy. 2017;31(2):495-502. See the summary.

Batakov, E. A. Effect of Silybum marianum oil and legalon on lipid peroxidation and hepatic antioxidant systems in rats intoxicated with carbon tetrachloride. Eksp.Klin Farmakol. 2001;64(4):53-55. See the summary. Seidlová-Wuttke D, Becker T, Christoffel V, Jarry H, Wuttke W. Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur, but no effect or anti-estrogen in the uterus of ovariectomized rats (ovx). J Steroid Biochem Mol Biol. 2003;86(2):179-88.

See the summary. This document does not contain all possible side effects and others may occur. Consult your doctor for more information about side effects. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral agents of type 2 diabetes in patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. See the summary. Jowkar F, Godarzi H, Parvizi MM.

Can silymarin be considered a treatment option for vitiligo? A randomized, double-blind controlled clinical trial of phototherapy combined with an oral product of Silybum Marianum compared to phototherapy alone. J dermatological treatment. 2020;31(3):256-60. See the summary. Holtmann G, Madisch A, Jürgen H, et al. A double-blind, randomized, placebo-controlled study of the effect of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Diseases Week 1999 May. Sonnenbichler J, Scalera F, Sonnenbichler I, Weyhenmeyer R.

Stimulating effects of silibin and silicistine from milk thistle Silybum marianum on renal cells. J Pharmacol Exp Ther 1999;290:1375-83. Sonnenbichler, J. and Zetl, I. Biochemical effects of silibin flavonolignan on RNA, protein and DNA synthesis in rats. Prog.Clin Biol Res 1986;213:319-331. Some drugs are pumped into the cells. Milk thistle can make these pumps less active and increase the amount of certain medications absorbed by the body. This can cause more side effects of certain medications. Some drugs moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quidine and others. Xiao F, Gao F, Zhou S, Wang L. The therapeutic effects of silymarin in patients with metabolic glucose/lipid dysfunction: a meta-analysis.

Medicine (Baltimore). 2020;99(40):e22249. See the summary. Lang, I., Deak, G., Nekam, K., Muzes, G., Gonzalez-Cabello, R., Gergely, P. and Feher, J. Hepatoprotective and immunomodulatory effects of antioxidant therapy. Acta Med Hung. 1988;45(3-4):287-295. Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S.

Antioxidant effects of silymarin on reducing liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: a clinical study. J Biochem Mol Toxicol 2021. See the summary. Boari, C., Montanari, F. M., Galletti, G. P., Rizzoli, D., Baldi, E., Caudarella, R. and Gennari, P. [Toxic occupational liver diseases. Therapeutic effects of silymarin].

Minerva Med 1981-10-20;72(40):2679-2688. Milk thistle: effects on liver disease and cirrhosis and clinical side effects. Executive Summary, Evidence Report/Technology Assessment: Issue 21, September 2000. Agency for Health Research and Quality, Rockville, MD. Available from: www.ahrq.gov/clinic/epcsums/milktsum.htm Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Medicine Metab disposes. 2014;42(10):1611-6. See the summary. Gamissans M, Expósito-Serrano V, López-Llunell C, Valdivieso L, Garbayo-Salmons P. Bullous pemphigoid caused by Silybum marianum: an unexpected side effect of an herbal remedy. Int J Dermatol.

7 August 2021 doi: 10.1111/ijd.15822. See the summary. Some medications are modified and broken down by the liver. Milk thistle can decrease how quickly the liver breaks down certain medications. Taking milk thistle with certain medications that are broken down by the liver can increase the effects and side effects of these medications. Before taking milk thistle, talk to your doctor if you are taking medications that are impaired by the liver. Some liver-modified medications include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others. Tóth B, Németh D, Soós A, et al. The effects of a fixed combination of Berberis aristata and Silybum marianum on dyslipidemia – A meta-analysis and systematic review.

Planta Med. 2019. See the summary. Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, et al. Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol Toxicol 2000;86:250-6. Moosavifar, N., Mohammadpour, A. H., Jallali, M., Karimiz, G., and Saberi, H. Evaluation of the effect of silymarin on apoptosis and follicle development of granulosa cells in patients undergoing in vitro fertilization. East Mediterr.Health J. 2010;16(6):642-645. Wenzel, S., Stolte, H.

and Soose, M. Effects of silibin and antioxidants on high glucose-induced changes in fibronectin turnover in human mesangial cell cultures. J Pharmacol Exp Ther 1996;279(3):1520-1526. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. Zhu W, Zhang JS, Young CY. Silymarin inhibits androgen receptor function by reducing the nuclear localization of the receptor in the LNCaP cell line of human prostate cancer. Carcinogenesis 2001;22:1399-403. Comoglio, A., Tomasi, A., Malandrino, S., Poli, G., und Albano, E.

Fängerwirkung von Silipid, einem neuen Silybin-Phospholipid-Komplex, auf aus Ethanol gewonnene freie Radikale. Biochem.Pharmacol 10-12-1995;50(8):1313-1316. Zusammenfassung anzeigen. Bidalic drugs are used in the treatment of acute and chronic viral hepatitis, alcohol, drugs, fatty liver disease and dysfunction. To take Amtim safely and effectively, you should refer to. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Eine in vitro Bewertung der humanen Cytochrome P450 3A4 Hemmung durch ausgewählte kommerzielle Kräuterextrakte und Tinkturen. Phytomedicine 2000;7:273-82. Zusammenfassung anzeigen. Grungreiff K, Albrecht M und Strenge-Hesse A. Nutzen der medikamentösen Lebertherapie in der Allgemeinmedizin. Med Welt 1995;46:222-227.

Chalasani N, Younossi Z, Lavine JE, et al. Die Diagnose und Behandlung von nicht-alkoholischen Fettlebererkrankungen: Praxisrichtlinie der American Association for the Study of Liver Diseases, des American College of Gastroenterology und der American Gastroenterological Association.